Nance Lab
Disease-Directed Engineering
Publications
Contributed Equally; *Corresponding
2023
60. Zhang F., Zhang Z., Alt J., Kambhampati S.P., Sharma A., Singh S., Nance E., Thomas A.G., Rojas C., Rais R., Slusher B.S., Kannan R.M., Sujatha Kannan S.* Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy,
Journal of Controlled Release (2023) 358: 27-42
59. Xu N., Wong M., Balistreri G.m Nance E. Neonatal Pharmacokinetics and Biodistribution of Polymeric Nanoparticles and Effect of Surfactant. Pharmaceutics. 2023 Apr 7;15(4):1176. doi: 10.3390/pharmaceutics15041176
2022
58. Dahl V. , Helmbrecht H., Rios Sigler A., Hildahl K., Sullivan H., Janakiraman S., Jasti S., Nance E.* Characterization of a mGluR5 knockout rat model with hallmarks of Fragile X Syndrome. Life (2022); 12(9): 1308; doi: 10.3390/life12091308
57. McKenna M., Filteau J., Sluis K., Chungyoun M., Butler B., Schimek N., Nance E.* Organotypic whole hemisphere brain slice models to study the effects of donor age and oxygen-glucose-deprivation on the extracellular properties of cortical and striatal tissue; Journal of Biological Engineering (2022); 16:14; doi: 10.1186/s13036-022-00293-w
56. Nyambura, C. W.; Sampath, J.; Nance, E.; Pfaendtner, J.* Exploring Structure and Dynamics of the PLGA-PEG Copolymer and its Homopolymer Constituents in Various Solvents Using All-Atom Molecular Dynamics. Journal of Applied Polymer Science (2022); doi: 10.1002/app.52732
55. Helmbrecht H. and Nance E.* Effective Laboratory Education with TEXTILE: Tutorials in ExeprimentalisT Interactive Learning. Chemical Engineering Education (2022); doi: 10.18260/2-1-370.660-129820.
54. Kolnik S., Corry K., Hildahl K., Filteau J., White O., Brandon O., Farid L., Shearlock AM, Moralejo D., Juul S.E., Nance E., Wood T.R. Vitamin E Decreases Cytotoxicity and Mitigates Inflammatory and Oxidative Stress Responses in a Ferret Organotypic Brain Slice Model of Neonatal Hypoxia-Ischemia. Developmental Neurosci. (2022) doi: 10.1159/000522485
53. Joseph A.* and Nance E.* Nanotherapeutics and the brain. Annual Reviews in Chemical & Biomolecular Engineering; (2022) 13:5.1-15.22, doi: 10.1146/annurev-chembioeng-092220-030853
52. Gornalusse G., Zhang M., Wang R., Rwigamba E., Kirby A.C., Fialkow M., Nance E., Hladik F. and Vojtech L. HSV-2 infection enhances Zika virus infection of primary genital epithelial cells independently of the known ZIKV receptor AXL. Frontiers Microbiology Front. Microbiology (2022); doi.org: 10.3389/fmicb.2021.825049
51. Nguyen, N.P., Helmbrecht H., Ye Z., Adebayo T., Hashi N., Doan M-A., Nance E. Brain tissue derived extracellular vesicles for therapeutic in neonatal ischemic brain injury. International Journal of Molecular Sciences, International J. of Molecular Sciences (2022) 23(2): 620; doi: 10.3390/ijms23020620
50. Nyambura C., Examining the Effect of Polymer Extension on Protein–Polymer Interactions That Occur during Formulation of Protein-Loaded Poly(lactic acid-co-glycolic acid)-polyethylene Glycol Nanoparticles
49. Wood T.R., Hildahl K., Helmbrecht H., Corry K.A., Moralejo D.H., Kolnik S.E., Prater K.E., Juul S.E., Nance E.* A ferret brain slice model of oxygen-glucose deprivation captures regional responses to perinatal injury and treatment associated with specific microglial phenotypes. Bioeng & Transl. Med (2022), e10265, doi: 10.1002/btm2.10265; PDF
48. Nance E.*, Pun S.*, Saigal R.*, Sellers D.* Drug delivery to the central nervous system. Nature Reviews Materials (2022), doi: 10.1038/s41578-021-00394-w; PDF
2021
47. Joseph A., Motchoffo Simo G., Gao T., Alhindi N., Nance E.* Surfactants influence polymeric nanoparticle fate in the brain. Biomaterials (2021) 277: 121086, doi: 10.1016/j.biomaterials.2021.121086 PDF
46. Helmbrecht H., Xu N., Liao R. Nance E.* Data management schema design for effective nanoparticle formulation for neurotherapeutics. AIChE Journal (2021), e17459; doi: 10.1002/aic.17459; PDF
45. Joseph A., Nyambura C., Bondurant D., Corry K., Beebout D., Wood T., Pfaendtner J., Nance E.* Formulation and efficacy of catalase-loaded nanoparticles for the treatment of neonatal hypoxic-ischemic encephalopathy. Pharmaceutics (2021) 13(8), 1131; doi: 10.3390/pharmaceutics13081131 PDF
44. McKenna M., Shackelford D., Ferreira Pontes H., Ball B., Nance E.* Multiple particle tracking detects changes in brain extracellular matrix and predicts neurodevelopment age. ACS Nano (2021), 15(5):8559-8573; doi: 10.1021/acsnano.1c00394; PDF
43. Helmbrecht H., Nance E.* Effective Laboratory Education with TEXTILE: Tutorials in EXperimentalisT Interactive LEarning (2021) Chemical Engineering Education; doi: 10.18260/2-1-370.660-129820
2020
42. Liao R., Wood T., Nance E.* Nanotherapeutic modulation of excitotoxicity and oxidative stress in acute brain injury. Nanobiomedicine (2020) 7:1-18; doi.org/10.1177/1849543520970819; PDF
41. Joseph A., Liao R., Zhang M., Helmbrecht H., McKenna M., Filteau J., Nance E.* Nanoparticle-microglial interaction in the ischemic brain is modulated by injury duration and treatment. Bioengineering & Translational Medicine (2020) August; doi.org/10.1002/btm2.10175; PDF
40. Helmbrecht H., Joseph A., Zhang M., McKenna M., Nance E.* Governing transport principles for nanotherapeutic applications in the brain. Current Opinion in Chemical Engineering (2020) 30:112-119 doi.org/10.1016/j.coche.2020.08.010; PDF
39. Liao R., Pon J., Chungyoun M., Nance E.* Enzymatic protection and biocompatibility screening of enzyme-loaded polymeric nanoparticles for neurotherapeutic applications. Biomaterials (2020) July; 257. doi: 10.1016/j.biomaterials.2020.120238; PDF
38. Chua C., Ho J., Susnjar A., Lolli G., Di Trani N., Pesaresi F., Sizovs A., Zhang M., Nance E., Grattoni A.* Intratumoral nanofluidic system enhances tumor biodistribution of CD40 antibody in triple negative breast cancer. Advanced Therapeutics (2020) July; doi: 10.1002/adtp.202000055; PDF
37. Zhang M., Vojtech L., Ye Z., Hladik F., Nance E.* Quantum dot labeling and visualization of extracellular vesicles. ACS Applied Nano Materials (2020) June 15; 7(3):7211-7222. doi: 10.1021/acsanm.0c01553; PDF
36. Liao R., Wood T.R., Nance E*. Superoxide dismutase reduces monosodium glutamate-induced injury in an organotypic whole hemisphere brain slice model of excitotoxicity. J Biol Eng (2020) Feb 4; 14:3. doi: 10.1186/s13036-020-0226-8; PDF
2019
35. Curtis C.D., McKenna M., Pontes H., Toghani D., Choe A., Nance E.* Predicting in situ nanoparticle behavior using multiple particle tracking and artificial neural networks. Nanoscale (2019) Nov 28; 11(46):22515-22530. doi: 10.1039/c9nr06327g. PDF
34. Vojtech L., Zhang M., Dave V., Levy C., Hughes S.M., Wang R., Calienes F., Prlic M., Nance E., Hladik F. Extracellular vesicles in human semen modulate antigen-presenting cell function and decrease downstream antiviral T cell responses. PLOS ONE (2019) Oct 17; 14(10):e0223901. doi: 10.1371/journal.pone.0223901 PDF
33. Wood T., Nance E.* Disease-directed engineering for physiology-driven treatment interventions. APL Bioengineering (2019) Oct 23; 3(4):040901. doi: 10.1063/1.5117299 PDF
32. Yellepeddi V, Joseph A., Nance E.* Pharmacokinetics of nanotechnology-based formulations in pediatric populations. Adv. Drug. Del. Rev. (2019) Nov; 151:44-55. doi: 10.1016/j.addr.2019.08.008 PDF
31. Zhang M., Bishop B., Thompson N., Hildahl K., Dang B., Mironchuk O., Chen N., Aoki R., Holmberg V.,* Nance E.* Quantum dot cellular uptake and toxicity in the developing brain: implications for use as imaging probes. Nanoscale advances (2019) 1, 3424-3442. doi: 10.1039/C9NA00334G PDF
30. Nance E.* Careers in nanomedicine and drug delivery. Adv. Drug. Del. Rev. (2019) Apr; 144:180-189. doi: 10.1016/j.addr.2019.06.009 PDF
29. Millik S.C., Dostie A.M., Karis D.G., Smith P.T., Mckenna M., Chan N., Curtis C.D., Nance E., Theberge A.B., Nelson A.* 3D printed coaxial nozzles for the extrusion of hydrogel tubes toward modeling vascular endothelium. Biofabrication (2019) Jul 12; 11(4):045009. doi: 10.1088/1758-5090/ab2b4d. PDF
2018
28. Wood T., Moralejo D., Corry K., Snyder J., Traudt C., Curtis C., Nance E., Parikh P., Juul S.* A ferret model of encephalopathy of prematurity, Developmental Neuroscience (2018) 40(5-6):475-489. doi: 10.1159/000498968. PDF
27. Curtis C., Toghani D., Wong B., Nance E.* Colloidal stability as a determinant of nanoparticle behavior in the brain. Colloids and Surfaces B: Biointerfaces (2018) 170, 673-682. doi: 10.1016/j.colsurfb.2018.06.050. PDF
26. Joseph A., Wood T., Chen C-C., Corry K., Juul S., Snyder J., Parikh P., Nance E.* Curcumin-loaded brain penetrating nanoparticles for treatment of neonatal hypoxia-ischemia encephalopathy. Nano Research (2018) 11(10): 5670-5688. doi: 10.1007/s12274-018-2104-y. PDF
25. Alnasser Y., Kambhampti S.P., Nance E., Rajbhandari L., Shrestha S., Venkatesan A., Kannan R.M., Kannan S.* Preferential and increased uptake of hydroxyl-terminated PAMAM dendrimers by activated microglia in rabbit brain mixed glial culture. Molecules (2018) Apr 27; 23(5). doi: 10.3390/molecules23051025. PDF
24. Vornhagen J., Armistead B., Quach P., Santana-Ufret V., Boldenow E., Alishetti V., Melief C., Ngo L.Y., Whidbey C., Doran K.S., Curtis C., Nance E., Rajagopal L.* Group B streptococcus exploits vaginal epithelial exfoliation for ascending infection. J. Clinical Investigation (2018) May 1; 128(5):1985-1999. doi: 10.1172/JCI97043. PDF
2017
23. Zhang C., Mastorakos P., Sobral M., Berry S., Song E., Nance E., Eberhard C.G., Hanes J., Suk J.S. Strategies to enhance the distribution of nanoparticles in the brain. J. Control Release (2017) Dec 10; 267:232-239. doi: 10.1016/j.jconrel.2017.07.028. PDF
22. Nance E., Kambhampati S.P., Smith E.S. Zhang Z., Zhang F., Singh S., Johnston M.V., Kannan R.M., Blue M.E., Kannan S.* Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett Syndrome. J. Neuroinflammation (2017) Dec 19; 14(1):252. doi: 10.1186/s12974-017-1004-5. PDF
21. Smith J., Sprenger K., Liao R., Joseph A., Nance E.,* Pfaendtner J.* Determining dominant driving forces affecting controlled protein release from polymeric nanoparticles. Biointerphases (2017) May 19; 12(2):02D412. doi: 10.1116/1.4983154. PDF
20. Zhang C., Nance E., Mastorakos P., Chisholm J., Berry S., Eberhart C., Tyler B., Brem H., Suk J.S., Hanes J.* Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats. J Control. Release (2017) Oct 10; 263:112-119. doi: 10.1016/j.jconrel.2017.03.007. PDF
19. Williams M., Zhang Z., Drewes J., Nance E., Singh S., Kannan S.* Maternal inflammation results in altered tryptophan metabolism in rabbit placenta and fetal brain. Developmental Neuroscience (2017) 39(5):399-412. doi: 10.1159/000471509. PDF
18. Nance E.* Brain penetrating nanoparticles for analysis of the brain microenvironment. Methods Mol. Biol. (2017) 1570:91-104. doi: 10.1007/978-1-4939-6840-4_6. PDF
2016
17. Curtis C., Zhang M., Liao R., Wood T., Nance E.* Systems-level thinking for nanoparticle-mediated therapeutic delivery to neurological diseases. Wiley Interdiscip Rev Nanomed Nanobiotechnol. (2016) Mar; 9(2). doi: 10.1002/wnan.1422. PDF
ϮSelected cover image: Curtis C., Zhang M., Liao R., Wood T. and Nance E.* Cover Image, Volume 9, Issue 2. WIREs Nanomed Nanobiotechnol, (2017) 9: n/a, e1463. doi:10.1002/wnan.1463.
16. Zhang F., Nance E., Zhang Z., Jasty V., Mishra M.K., Kambhampati S.P., Burd I., Romero R., Kannan R., Kannan S.* Surface functionality affects the biodistribution and microglia-targeting of intra-amniotically delivered dendrimers. J Control. Release, (2016) Sep 10; 237:61-70. doi: 10.1016/j.jconrel.2016.06.046. PDF
15. Nance E., Zhang F., Mishra M.K., Zhang Z., Kambhampati S.P., Kannan R.M.*, Kannan S.* Nanoscale effects in dendrimer-mediated targeting of neuroinflammation. Biomaterials (2016) Sep; 101:96-107. doi: 10.1016/j.biomaterials.2016.05.044. PDF
14. Zhang Z., Bassam B., Thomas AG., Williams M., Liu J., Nance E., Rojas C., Slusher BS., Kannan S.* Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain. Neurobiol. Dis. (2016) Oct; 94:116-28. doi: 10.1016/j.nbd.2016.06.010. PDF
13. Zhang F., Nance E., Alnasser Y., Kannan R., Kannan S.* Microglial migration and interactions with dendrimer nanoparticles are altered in the presence of neuroinflammation. J Neuroinflammation (2016) Mar 22; 13(1):65. doi: 10.1186/s12974-016-0529-3. PDF
2015 and prior
12. Nance E., Porambo M., Mishra M.K., Zhang F., Buelow M., Getzenberg R., Johnston M., Kannan R., Fatermi S-A, Kannan S.* Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury. J Control. Release, (2015) Sep 28; 214:112-20. doi: 10.1016/j.jconrel.2015.07.009. PDF
11. Nance E., Zhang C., Shih T-Y, Xu Q., Schuster B., Hanes J.* Brain penetrating nanoparticles improve paclitaxel efficacy in malignant gliomas following local administration. ACS Nano (2014) Oct 28; 8(10):10655-64. doi: 10.1021/nn504210g. PDF
10. Nance E., Timbie K., Miller W.G., Song J., Louttit C., Klibanov A.L., Shih T-Y, Swaminathan G., Tamargo R.J., Woodworth G., Hanes J., Price R.J.* Noninvasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound. J Control. Release, (2014) Sep 10; 189:123-132. doi: 10.1016/j.jconrel.2014.06.031. PDF
ϮControlled Release Society award for best paper of the year
9. Woodworth G.*, Dunn A., Nance E., Hanes J., Brem H. Emerging Insights into Barriers to Effective Brain Tumor Therapeutics. Frontiers NeuroOnc., (2014) 4:126. doi: 10.3389/fonc.2014.00126 PDF
8. Birjiniuk A., Billings B., Nance E., Hanes J., Ribbeck K., Doyle S.P.* Single particle tracking reveals spatial and dynamic organization of the Escherichia coli biofilm matrix. New J Physics (2014) Aug 27; 16(8):085014. doi: 10.1088/1367-2630/16/8/085014. PDF
7. Kannan R., Nance E., Kannan S., Tomalia D.* Emerging concepts in dendrimer nanomedicine: translational aspects. J Internal Medicine, (2014) 276(6): 579-617. doi: 10.1111/joim.12280 PDF
6. Balakrishnan B., Nance E., Johnston M., Kannan S.* Nanomedicine in cerebral palsy. Int. J Nanomedicine (2013) 8:4183-4195. doi: 10.2147/IJN.S35979 PDF
5. Lesniak W., Mishra M.K., Jyoti A., Balakrishnan B., Zhang F., Nance E., Romero R., Kannan S., Kannan R.* Biodistribution of Fluorescently-labeled PAMAM Dendrimers in Neonatal Rabbits: Effect of Neuroinflammation. Mol. Pharmaceutics (2013) Dec 2; 10(12):4560-71. doi: 10.1021/mp400371r. PDF
4. Xu Q., Boylan N., Suk J., Wang Y-Y, Nance E., Yang J-C, McDonnell P., Cone R., Duh E., Hanes J.* Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo. J Control Release. (2013) Apr 10; 167(1):76-84. doi: 10.1016/j.jconrel.2013.01.018. PDF
ϮSelected Cover Image
3. Nance E., Woodworth G., Sailor K., Shih T-Y, Swaminathan G., Xiang D., Eberhart C., Hanes J.* A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue. Sci. Transl. Med. (2012) Aug 29; 4(149):149ra119. doi: 10.1126/scitranslmed.3003594. PDF
ϮSelected Cover Image
2. Navarette C., Sisson J., Nance E., Allen-Gipson D., Hanes J., Wyatt T.* Particulate matter in cigarette smoke increases ciliary axoneme beating through mechanical stimulation. J Aerosol. Med. Pulm. Drug Deliv. (2012) Jun; 25(3):159-68. doi: 10.1089/jamp.2011.0890. PDF
1. Montero C., Lewis D., Johnson M., Conners S., Nance E., Nichols J., Kelly R.* Colocation of genes encoding a tRNA-mRNA hybrid and a putative signaling peptide on complimentary strands in the genome of the hyperthermophilic bacterium Thermotoga maritima. J Bacteriol. (2006) Oct; 188(19):6802-7. doi: 10.1128/JB.00470-06. PDF
Research Software
diff_classifer: Curtis C., Rokem A., Nance E.* Diff_classifier: Particle tracking parallelization. Journal Open Source Software 4(36):989 doi: 10.21105.joss.00989 PDF
diff_predictor: Shackelford D., Nance E.
ifThreshold: Helmbrecht H., Zhou Q., Nance E. A Python package that uses thresholding, segmentation, and neuromorphology features to automatically score a variety of thresholds and machine learning to provide a ranked list of those thresholds for fluorescent cell images. Github
ifmodels: Helmbrecht H., Nance E. A Python package that uses image registration between brain images of entire slices obtained via confocal microscopy and a universal atlas to create 3D immunofluorescent models of rat brains. Github
cellmorphflows: Helmbrecht H., Nance E. A repository to hold our single experiment Jupiter notebook workflows for running the VAMPIRE process and analysis. Github
Used in Nanoparticle-microglial interaction in the ischemic brain is modulated by injury duration and treatment. Bioengineering & Translational Medicine (2020) August; doi.org/10.1002/btm2.10175
Books & Book Chapters
Filteau J., Butler B., Schimek N., Nance E.* (2022) Nano-Based Probes for the Brain Extracellular Environment. Book: Engineering Biomaterials for Neural Applications, 53-88; Editor: Elizabeth Nance; Published: Springer
Nance E.*, McKenna M. (2020). Challenges and barriers. Nanoparticles for Biomedical Applications, 89–107. doi:10.1016/b978-0-12-816662-8.00007-2 PDF
Editorials
7. Nance E.* Clinical agitation prevents sperm agglutination. Sci. Transl. Med. Editor’s Choice (2018); 11(478), eaaw5323.
6. Nance E.* Magnets make target cells more attractive to CRISPR. Sci. Transl. Med. Editor’s Choice (2018); 10(470), eaaw0520.
5. Nance E.* Predicting pathology provides prostate prognostication. Sci. Transl. Med. Editor’s Choice (2018); 10(462), eaav3886.
4. Nance E.* Platelets prefer to be shaken, not stirred. Sci. Transl. Med. Editor’s Choice (2018), 10(454), eaau7388.
3. Nance E.* Ketogenic bugs as epileptic drugs. Sci Transl. Med. Editor’s Choice (2018), 10(446), eaau0471.
2. Nance E.* Nano livers: A sobering Discovery. Sci Transl. Med. Editor’s Choice (2018), 10(438), eaat4479.
1. Nance E.* GO minions – polarize and repair! Sci. Transl. Med Editor’s Choice (2018), 10(430), eeas8967.